Biosynther

BioSynther is an interactive platform for exploring biosynthetic potentials of precursor chemicals. It integrates 60,000+ manually curated reactions from scientific literature with BKM-react and Rhea databases, enabling step-by-step discovery of novel pathways to synthesize high-value compounds like biofuels and pharmaceuticals from simple starting molecules.

The tool employs a customized Dijkstra's algorithm to search biochemical reaction networks, visualized through dynamic tree, circle, and graph views. Users interactively explore multi-step pathways (e.g., vanillin → 8 derivatives in one step), click nodes to inspect compound structures, and access reaction references for experimental validation.

BioSynther accelerates metabolic engineering by transforming precursor chemicals into actionable biosynthesis targets. Its intuitive interface supports real-time pathway exploration, making it essential for designing efficient microbial cell factories in synthetic biology.